Remyelination protects neurons from DLK-mediated neurodegeneration.
Duncan GJ, Ingram SD, Emberley K, Hill J, Cordano C, Abdelhak A, McCane M, Jenks JE, Jabassini N, Ananth K, Ferrara SJ, Stedelin B, Sivyer B, Aicher SA, Scanlan TS, Watkins TA, Mishra A, Nelson JW, Green AJ, Emery B
Nat Commun. 2024 Oct 23;15(1):9148. doi: 10.1038/s41467-024-53429-5.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 208834 | AAV-U6-sgLacZ-U6-sgGFP-hSyn1-mCherry | Control plasmid expresses mCherry under the hSyn1 promoter with sgRNAs against LacZ and GFP |
| 208835 | AAV-U6-sgMap3K12(1)-U6-sgMap3K12(2)-hSyn1-mCherry | Knockout of Map3K12 (DLK) using tandem sgRNAs, expresses mCherry under the hSyn1 promoter |
| 208836 | AAV-U6-sgMap3K13(1)-U6-sgMap3K13(2)-hSyn1-mCherry | Knockout of Map3K13 (LZK) using tandem sgRNAs, expresses mCherry under the hSyn1 promoter |
| 208837 | AAV-U6-sgMap3K13(1)-U6-sgMap3K12(1)-hSyn1-mCherry | Knockout of Map3K12 (DLK) and Map3K13 (LZK) using tandem sgRNAs, expresses mCherry under the hSyn1 promoter |