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A rationally designed optochemogenetic switch for activating canonical Wnt signaling.

Lee S, Cui M, Lee D, Han K, Sun W, Lee D
iScience. 2023 Feb 19;26(3):106233. doi: 10.1016/j.isci.2023.106233. eCollection 2023 Mar 17. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
221773pCMV:: PDGFR-Cry2olig-FRBExpresses PDGFR-Cry2olig-FRB component in mammalian cells
221774pCMV:: NES-FKBP-iLID-LRP6cExpresses NES-FKBP-iLID-LRP6c component in mammalian cells
221775pCMV:: NES-FKBP-iLID-LRP6c(△1-64)Expresses NES-FKBP-iLID-LRP6c(△1-64) component in mammalian cells
221776pCMV:: PDGFR-Cry2olig-FRB-P2A-GFP(1-10)Expresses PDGFR-Cry2olig-FRB-P2A-GFP(1-10) component in mammalian cells
221777pCMV:: GFP11x7-P2A-NES-FKBP-iLID-LRP6c(△1-64)Expresses GFP11x7-P2A-NES-FKBP-iLID-LRP6c(△1-64) component in mammalian cells
2217787xTCF-SEAPSEAP reporter vector for optochemoWnt system

Antibodies from Article