Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier.
Huang Q, Chen AT, Chan KY, Sorensen H, Barry AJ, Azari B, Zheng Q, Beddow T, Zhao B, Tobey IG, Moncada-Reid C, Eid FE, Walkey CJ, Ljungberg MC, Lagor WR, Heaney JD, Chan YA, Deverman BE
PLoS Biol. 2023 Jul 19;21(7):e3002112. doi: 10.1371/journal.pbio.3002112. eCollection 2023 Jul.
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Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 203532 | iCAP-BI-28-KanR | RepCap for AAV production |
| 203533 | iCAP-BI-48-KanR | RepCap for AAV production |
| 203534 | iCAP-BI-49-KanR | RepCap for AAV production |
| 203535 | iCAP-BI-62-KanR | RepCap for AAV production |
| 203536 | iCAP-BI-65-KanR | RepCap for AAV production |
| 203539 | AAV-CAG-SV40NLSf-mScarlet-P2A-hLuc-WPRE | AAV reporter genome plasmid |
| 203540 | AAV-GfABC1D-SaCas9-WPRE3-pA | SaCas9 expression in astrocytes |
| 203541 | AAV-GfABC1D-NLS-GFP-WPRE-synpA-L1-R2 | gRNA expression in astrocytes |