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Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.

Gaynor KU, Vaysburd M, Harman MAJ, Albecka A, Jeffrey P, Beswick P, Papa G, Chen L, Mallery D, McGuinness B, Van Rietschoten K, Stanway S, Brear P, Lulla A, Ciazynska K, Chang VT, Sharp J, Neary M, Box H, Herriott J, Kijak E, Tatham L, Bentley EG, Sharma P, Kirby A, Han X, Stewart JP, Owen A, Briggs JAG, Hyvonen M, Skynner MJ, James LC
Nat Commun. 2023 Jun 16;14(1):3583. doi: 10.1038/s41467-023-39158-1. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
194999pExp-His-zBasic-RBDProduction of SARS-CoV2 receptor binding domain in E. coli

Antibodies from Article