Engineering RsDddA as mitochondrial base editor with wide target compatibility and enhanced activity.
Cheng K, Li C, Jin J, Qian X, Guo J, Shen L, Dai Y, Zhang X, Li Z, Guan Y, Zhou F, Tang J, Zhang J, Shen B, Lou X
Mol Ther Nucleic Acids. 2023 Sep 9;34:102028. doi: 10.1016/j.omtn.2023.09.005. eCollection 2023 Dec 12.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 205463 | pGL3-MTS-CCDB-N136-RsDddA-A-UGI-PURO | A backbone containing a RsDddA fragment A for constructing mitochondria-targeted RsDdCBE expression plasmid |
| 205464 | pGL3-MTS-CCDB-N136-RsDddA-B-UGI-PURO | A backbone containing a RsDddA fragment B for constructing mitochondria-targeted RsDdCBE expression plasmid |
| 205465 | pGL3-MTS-CCDB-N136-RsDddA-C-UGI-PURO | A backbone containing a RsDddA fragment C for constructing mitochondria-targeted RsDdCBE expression plasmid |
| 205466 | pGL3-MTS-CCDB-N136-RsDddA-D-UGI-PURO | A backbone containing a RsDddA fragment D for constructing mitochondria-targeted RsDdCBE expression plasmid |