Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer's disease.
Owlett LD, Karaahmet B, Le L, Belcher EK, Dionisio-Santos D, Olschowka JA, Elliott MR, O'Banion MK
J Neuroinflammation. 2022 Feb 7;19(1):38. doi: 10.1186/s12974-022-02397-y. PubMed Article
Owlett LD, Karaahmet B, Le L, Belcher EK, Dionisio-Santos D, Olschowka JA, Elliott MR, O'Banion MK
J Neuroinflammation. 2022 Feb 7;19(1):38. doi: 10.1186/s12974-022-02397-y. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 202540 | pOTTC1663 - pAAV SYN1 mGas6-Myc-DDK | An adeno-associated viral vector expressing murine Gas6 fused Myc and DDK epitopes from a synapsin promoter |
| 202541 | pOTTC1664 - pAAV SYN1 mGas6(delta)-Myc-DDK | An adeno-associated viral vector expressing murine Gas6 with deletion of (F50-E275) fused Myc and DDK epitopes from a synapsin promoter |