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Experimental VLP vaccine displaying a furin antigen elicits production of autoantibodies and is well tolerated in mice.

Lampinen V, Ojanen MJT, Caro FM, Grohn S, Hankaniemi MM, Pesu M, Hytonen VP
Nanoscale Adv. 2024 Oct 9;6(24):6239-52. doi: 10.1039/d4na00483c. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
201193SpyCatcher-P-DomainExpresses furin P-domain genetically fused to SpyCatcher001 in bacteria
201194SpyCatcher-SWGExpresses a peptide from the active site of furin genetically fused to SpyCatcher001 in bacteria
201195SpyCatcher-PEEDExpresses a peptide from the LDL receptor binding site of PCSK9 genetically fused to SpyCatcher001 in bacteria
201196SpyCatcher-DIIGExpresses a peptide from the LDL receptor binding site of PCSK9 genetically fused to SpyCatcher001 in bacteria

Antibodies from Article