Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization.
Schwalm MP, Kramer A, Dolle A, Weckesser J, Yu X, Jin J, Saxena K, Knapp S
Cell Chem Biol. 2023 Jun 20:S2451-9456(23)00157-5. doi: 10.1016/j.chembiol.2023.06.002.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 200880 | HaloTag-WDR5 | Mammalian expression of human WDR5 with N-terminal HaloTag fusion |
| 200881 | WDR5-HaloTag | Mammalian expression of human WDR5 with C-terminal HaloTag fusion |
| 200882 | pF-N-HiBiT-template | template for N-terminal HiBIT-tagging |
| 200883 | pNIC28-HiBIT-WDR5 | Bacterial expression of N-terminal HiBIT-tagged human WDR5 protein |