Precise homology-directed installation of large genomic edits in human cells with cleaving and nicking high-specificity Cas9 variants.

Wang Q, Liu J, Janssen JM, Goncalves MAFV
Nucleic Acids Res. 2023 Mar 17:gkad165. doi: 10.1093/nar/gkad165. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

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ID	Plasmid	Purpose
199238	AY27_pU6.gRNA.CLYBL	Expression construct encoding a S. pyogenes guide RNA targeting the human CLYBL safe harbor locus
199237	AM77_pU6.Sa-gRNA.CLYBL	Expression construct encoding a S. aureus guide RNA targeting the human CLYBL safe harbor locus
199228	AZ64_pE.DonorCLYBL.TS	Donor plasmid with CLYBL target sites for ITPN or HMEJ knock-in at the human CLYBL safe harbor locus
199227	AD59_pEP.DonorCLYBL.TS	Donor plasmid with CLYBL target sites for ITPN or HMEJ knock-in at the human CLYBL safe harbor locus
199223	BB44_pmc.DonorR5.TS	Donor plasmid with CCR5 target sites for ITPN or HMEJ knock-in at the human CCR5 safe harbour locus