Transient inhibition of p53 enhances prime editing and cytosine base-editing efficiencies in human pluripotent stem cells.

Li M, Zhong A, Wu Y, Sidharta M, Beaury M, Zhao X, Studer L, Zhou T
Nat Commun. 2022 Oct 27;13(1):6354. doi: 10.1038/s41467-022-34045-7. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

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Search table:

ID	Plasmid	Purpose
199278	Lsg-LMNA-1 + 2	nicking sgRNA to induce LMNA (c.1824C > T) mutation using PE3
199277	Lsg-LRRK2-1	nicking sgRNA to induce LRRK2 (c. 6055 G > A) mutation using PE3
199276	Lsg-GBA-1 + 2	nicking sgRNA to induce or correct GBA (c. 1226 A > G) mutation using PE3
199275	pegRNA_LMNA_CR-2-5	pegRNA used to correct LMNA (c.1824C > T) mutation
199274	pegRNA_GBA-4	pegRNA used to correct GBA (c. 1226 A > G) mutation
199273	pegRNA_LMNA-1	pegRNA used to induce LMNA (c.1824C > T) mutation
199272	pegRNA_LRRK2-3	pegRNA used to induce LRRK2 (c. 6055 G > A) mutation
199271	pegRNA-GBA-10	pegRNA used to induce GBA (c. 1226 A > G) mutation
199267	pEF_PE2	Mammalian expression of SpCas9 prime editor 2 under EF1α promoter
196582	pCMV-PE2-p53DD	Mammalian expression of SpCas9 prime editor 2 with P2A-p53DD