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Systematic interrogation of tumor cell resistance to CAR T cell therapy in pancreatic cancer.

Hagel KR, Arafeh R, Gang S, Arnoff TE, Larson RC, Doench JG, Mathewson ND, Wucherpfennig KW, Maus MV, Hahn WC
Cancer Res. 2022 Dec 22:CAN-22-2245. doi: 10.1158/0008-5472.CAN-22-2245. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
193450pXPR_003_sgTFAP4 guide 1ko TFAP4 guide 1
193585pXPR_003 Intergenic control guide 2sgRNA control; induces CAS9 cutting in an intergenic region
193586pXPR_003_sgTFAP4 guide 1TFAP4 knockout
193587pXPR_003_sgTFAP4 guide 2TFAP4 knockout
193588pXPR_003 sgMSLNMSLN knockout
193589pXPR_003 sgFADD guide 1FADD knockout
193590pXPR_003 sgFADD guide 2FADD knockout
193591pXPR_003 sgRELA guide 1RELA knockout
193592pXPR_003 sgRELA guide 2RELA knockout
193593pXPR_003 sgNFkB2 guide 1NFkB2 knockout
193594pXPR_003 sgNFkB2 guide 2NFkB2 knockout
193595pXPR_003 sgNFkBIA guide 1NFkBIA knockout
193596pXPR_003 sgNFkBIA guide 2NFkBIA knockout
193597pXPR_003 sgMYC guide 2cMYC knockout
193598pXPR_003 sgSNRPA guide 1SNRPA knockout
193599pXPR_003 sgSNRPA guide 2SNRPA knockout
193600pXPR_003 sgAP2M1 guide 1AP2M1 knockout
193601pXPR_003 sgAP2M1 guide 2AP2M1 knockout
193602pXPR_003 sgPGD guide 1PGD knockout
193603pXPR_003 sgPGD guide 2PGD knockout
193604pXPR_003 sgSMARCA4 guide 1SMARCA4 knockout
193605pXPR_003 sgSMARCA4 guide 2SMARCA4 knockout
193606pXPR_003 sgINTS12 guide 1INTS12 knockout
193607pXPR_003 sgINTS12 guide 2INTS12 knockout
193608pXPR_003 sgGPAA1 guide 1GPAA1 knockout
193609pXPR_003 sgGPAA1 guide 2GPAA1 knockout
193610pXPR_003 sgPIGA guide 1PIGA knockout
193611pXPR_003 sgPIGA guide 2PIGA knockout
193612pXPR_003 sgPIGW guide 1PIGW knockout
193613pXPR_003 sgPIGW guide 2PIGW knockout
193616pLX317 TFAP4Expresses TFAP4
193617pLX313 MSLNExpresses MSLN

Antibodies from Article