High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors.

Urfer R, Tsoulfas P, O'Connell L, Hongo JA, Zhao W, Presta LG
J Biol Chem. 1998 Mar 6;273(10):5829-40. doi: 10.1074/jbc.273.10.5829. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

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ID	Plasmid	Purpose
190205	pMEXneo-TrkC-TrkB-hybrid	To express a Human TrkC receptor that binds only BDNF. The second IgG like domain which is the main binding domain comes from the TrkB receptor
190204	pMEXneo-TrkC-Δ6	To express the human TrkC that has in the extracellular domain only the second IgG like domain. Still binds NT-3.
190203	pMEXneo-TrkB	To express the Human TrkB receptor under the Moloney mouse sarcoma virus LTR
190202	pMEXneo-TrkC	To express the Human TrkC receptor under the Moloney mouse sarcoma virus LTR.