Optogenetic activators of apoptosis, necroptosis, and pyroptosis.
Shkarina K, Hasel de Carvalho E, Santos JC, Ramos S, Leptin M, Broz P
J Cell Biol. 2022 Jun 6;221(6). pii: 213145. doi: 10.1083/jcb.202109038. Epub 2022 Apr 14.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 208780 | pLVX-Cry2olig | Inducibly expresses light activatable Cry2 domain |
| 208781 | pLVX-opto-mCasp1 | Inducibly expresses mouse caspase1 fused to light activatable Cry2 |
| 208782 | pLVX-opto-mCasp8 | Inducibly expresses mouse caspase8 fused to light-activatable Cry2 |
| 208783 | pLVX-opto-mRipK3 | Inducibly expresses mouse RipK3 fused to light activatable Cry2 |
| 208784 | pLVX-opto-mMLKL | Inducibly expresses mouse MLKL fused to light-activatable Cry2 |
| 208785 | pLVX-opto-hCaspase-4 dCARD | Inducibly expresses human Caspase 4 lacking the CARD domain, fused to light-activatable Cry2 |
| 208786 | pLVX-opto-hCaspase-8 | Inducibly expresses human Caspase 8 fused to light-activatable Cry2 |
| 208787 | pLVX-opto-hCaspase-9 | Inducibly expresses human Caspase 8 fused to light-activatable Cry2 |
| 208788 | pLVX-opto-hRIP3 dRHIM | Inducibly expresses human RIP3, lacking RHIM domain, fused to light-activatable Cry2 |
| 208789 | pLVX-opto-hMLKL | Inducibly expresses human MLKL, fused to light-activatable Cry2 |
| 208790 | pLVX-opto-hCaspase-1 | Inducibly expresses human Caspase1, fused to light-activatable Cry2 |