Engineered Cas12a-Plus nuclease enables gene editing with enhanced activity and specificity.
Huang H, Huang G, Tan Z, Hu Y, Shan L, Zhou J, Zhang X, Ma S, Lv W, Huang T, Liu Y, Wang D, Zhao X, Lin Y, Rong Z
BMC Biol. 2022 Apr 25;20(1):91. doi: 10.1186/s12915-022-01296-1.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 191230 | pCAG-LbCas12a-Plus-mCherry | To express the LbCas12a nuclease variant "LbCas12a-Plus" that enhanced the editing activity and specificity |
| 191231 | pCAG-AsCas12a-Plus-mCherry | To express the AsCas12a nuclease variant "AsCas12a-Plus" that enhanced the editing activity and specificity |