A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis.
Pahlevan Kakhki M, Giordano A, Starvaggi Cucuzza C, Venkata S Badam T, Samudyata S, Lemee MV, Stridh P, Gkogka A, Shchetynsky K, Harroud A, Gyllenberg A, Liu Y, Boddul S, James T, Sorosina M, Filippi M, Esposito F, Wermeling F, Gustafsson M, Casaccia P, Hillert J, Olsson T, Kockum I, Sellgren CM, Golzio C, Kular L, Jagodic M
Nat Commun. 2024 Jul 30;15(1):6419. doi: 10.1038/s41467-024-50794-z.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 190728 | P3-dCas9-Tet1-GFP-Puro | Expression of human spdCas9-Tet1 fusion for targeted DNA methylation in mammalian cell. EGFP-puromycin double marker under an independent CMV promoter. Cloning backbone for spgRNA (BbsI) |
| 190729 | P3-Lenti-dCas9-Tet1-GFP | Lentiviral construct to express spdCas9-Tet1-GFP. |