Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias.
Schihada H, Klompstra TM, Humphrys LJ, Cervenka I, Dadvar S, Kolb P, Ruas JL, Schulte G
J Biol Chem. 2022 Aug 3:102328. doi: 10.1016/j.jbc.2022.102328.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 190714 | G12-CASE | Encodes a BRET-based activity sensor for the heterotrimeric G protein G12. Composed of the subunits G alpha 12 (GNA12) tagged with NanoLuciferase, G beta 3 (GNB3) and Venus-tagged G gamma 9 (GNG9). |