Nested epistasis enhancer networks for robust genome regulation.

Lin X, Liu Y, Liu S, Zhu X, Wu L, Zhu Y, Zhao D, Xu X, Chemparathy A, Wang H, Cao Y, Nakamura M, Noordermeer JN, La Russa M, Wong WH, Zhao K, Qi LS
Science. 2022 Aug 11:eabk3512. doi: 10.1126/science.abk3512. PubMed Article

Plasmids from Article

ID	Plasmid	Purpose
190684	pSLQ1373_mU6_sgRNA targeting e1	sgRNA targeting enhancer 1 of MYC
190685	pSLQ1373_mU6_sgRNA targeting e3	sgRNA targeting enhancer 3 of MYC
190686	pSLQ5004_hU6_sgRNA targeting e4	sgRNA targeting enhancer 4 of MYC
190687	pSLQ5004_hU6_sgRNA targeting e7	sgRNA targeting enhancer 7 of MYC
190688	double_sgRNA targeting e1 and e4	sgRNAs targeting enhancer 1 and 4 of MYC separately
190689	double_sgRNA targeting e3 and e7	sgRNAs targeting enhancer 3 and 7 of MYC separately