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A transthyretin monomer intermediate undergoes local unfolding and transient interaction with oligomers in a kinetically concerted aggregation pathway.

Sun X, Ferguson JA, Dyson HJ, Wright PE
J Biol Chem. 2022 Jun 18;298(8):102162. doi: 10.1016/j.jbc.2022.102162. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
190008TTR C10S S46CExpression of human TTR in E coli
190009TTR C10S E63CExpression of human TTR in E coli
190010TTR C10S S100CExpression of human TTR in E coli

Antibodies from Article