Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter.
Jacobs MT, Zhang YW, Campbell SD, Rudnick G
J Biol Chem. 2007 Oct 5;282(40):29441-7. doi: 10.1074/jbc.M704456200. Epub 2007 Aug 13.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 190174 | pcDNA3.1_rSERT_C109A_Y107C | For expression of a SERT mutant in mammalian cells and measuring accessibility in the SERT extracellular pathway |