Mitochondrial base editor induces substantial nuclear off-target mutations.
Lei Z, Meng H, Liu L, Zhao H, Rao X, Yan Y, Wu H, Liu M, He A, Yi C
Nature. 2022 May 12. pii: 10.1038/s41586-022-04836-5. doi: 10.1038/s41586-022-04836-5.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 187845 | ND6-L1397-N_UGI-NES_left | expresses the left-side half ND6-UGI-NES in mammalian cells |
| 187846 | ND6-L1397-N_UGI-NES_right | expresses the right-side half ND6-UGI-NES in mammalian cells |
| 187847 | bpNLS-DddIA | expresses the bpNLS-linked DddIA in mammalian cells |
| 187848 | ND6-L1397-N_Q1310A_left | expresses the left-side half ND6-Q1310A in mammalian cells |
| 187849 | ND6-L1397-N_Q1310A_right | expresses the right-side half ND6-Q1310A in mammalian cells |