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Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry.

Kastenhuber ER, Mercadante M, Nilsson-Payant B, Johnson JL, Jaimes JA, Muecksch F, Weisblum Y, Bram Y, Chandar V, Whittaker GR, tenOever BR, Schwartz RE, Cantley L
Elife. 2022 Mar 23;11. pii: 77444. doi: 10.7554/eLife.77444. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
187482pEGPNExpression vector - GFP
187483pEGPN-ACE2Expression vector - ACE2
187484pEGPN-TMPRSS2Expression vector - TMPRSS2

Antibodies from Article