In vivo prime editing of a metabolic liver disease in mice.
Bock D, Rothgangl T, Villiger L, Schmidheini L, Matsushita M, Mathis N, Ioannidi E, Rimann N, Grisch-Chan HM, Kreutzer S, Kontarakis Z, Kopf M, Thony B, Schwank G
Sci Transl Med. 2022 Mar 16;14(636):eabl9238. doi: 10.1126/scitranslmed.abl9238. Epub 2022 Mar 16.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 187181 | AAV-p3-PE(1152)-N-term | p3-PE2-N-term(1152) in AAV2 backbone (ITRs) |
| 187182 | AAV-p3-PE(1153-dRnH)-C-term | p3-PE2-C-term(1153-dRnH) in AAV2 backbone (ITRs) targeting DNMT1 |