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A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers.

Koppula P, Lei G, Zhang Y, Yan Y, Mao C, Kondiparthi L, Shi J, Liu X, Horbath A, Das M, Li W, Poyurovsky MV, Olszewski K, Gan B
Nat Commun. 2022 Apr 22;13(1):2206. doi: 10.1038/s41467-022-29905-1. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
186459lentiCRISPR v2 sgKEAP1-2knock out KEAP1 in mammalian cells
186837lentiCRISPR v2 sgKEAP1-3knock out KEAP1 in mammalian cells
186838lentiCRISPR v2 sgNRF2-3knock out NRF2 in mammalian cells
186839lentiCRISPR v2 sgNRF2-4knock out NRF2 in mammalian cells

Antibodies from Article