Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.
Chen Z, Ioris RM, Richardson S, Van Ess AN, Vendrell I, Kessler BM, Buffa FM, Busino L, Clifford SC, Bullock AN, D'Angiolella V
Cell Death Differ. 2022 Apr 4. pii: 10.1038/s41418-022-00983-4. doi: 10.1038/s41418-022-00983-4.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 184624 | pCW57.1 KBTBD4 WT | Doxycycline inducible lentiviral vector for N-terminal Flag tagged KBTBD4 WT expression in mammalian cells |
| 184625 | pCW57.1 KBTBD4 P311PP | Doxycycline inducible lentiviral vector for N-terminal Flag tagged KBTBD4 P311PP expression in mammalian cells |
| 184626 | pCW57.1 KBTBD4 R313PRR | Doxycycline inducible lentiviral vector for N-terminal Flag tagged KBTBD4 R313PRR expression in mammalian cells |
| 184627 | pcDNA 3.1 KBTBD4 WT | Mammalian expression vector with N-terminal 3xFlag for KBTBD4 WT expression in mammalian cells |
| 184628 | pcDNA 3.1 KBTBD4 P311PP | Mammalian expression vector with N-terminal 3xFlag for KBTBD4 P311PP expression in mammalian cells |
| 184629 | pcDNA 3.1 KBTBD4 R313PRR | Mammalian expression vector with N-terminal Flag for KBTBD4 R313PRR expression in mammalian cells |
| 184630 | pcDNA 3.1 KBTBD4 R312RG | Mammalian expression vector with N-terminal Flag for KBTBD4 R312RG expression in mammalian cells |