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Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.

Mikolajek H, Weckener M, Brotzakis ZF, Huo J, Dalietou EV, Le Bas A, Sormanni P, Harrison PJ, Ward PN, Truong S, Moynie L, Clare DK, Dumoux M, Dormon J, Norman C, Hussain N, Vogirala V, Owens RJ, Vendruscolo M, Naismith JH
Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2205412119. doi: 10.1073/pnas.2205412119. Epub 2022 Jul 15. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
184277pOPINO_H11Expresses nanobody H11 in E. coli
184278pOPINOH11-A10Expresses nanobody H11-A10 in E. coli
184279pOPINO_H11-B5Expresses nanobody H11-B5 in E. coli
184280pOPINO_11-H6Expresses nanobody H11-H6 in E. coli
184281pOPINH11-H4 Q98R_H100EExpresses nanobody H11-H4 Q98R_H100Ein E. coli

Antibodies from Article