Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in ROS1 Fusion-Positive Lung Cancer.
Lin JJ, Choudhury NJ, Yoda S, Zhu VW, Johnson TW, Sakhtemani R, Dagogo-Jack I, Digumarthy SR, Lee C, Do A, Peterson J, Prutisto-Chang K, Malik W, Hubbeling HG, Langenbucher A, Schoenfeld AJ, Falcon CJ, Temel JS, Sequist LV, Yeap BY, Lennerz JK, Shaw AT, Lawrence MS, Ou SI, Hata AN, Drilon A, Gainor JF
Clin Cancer Res. 2021 May 15;27(10):2899-2909. doi: 10.1158/1078-0432.CCR-21-0032. Epub 2021 Mar 8.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 183813 | pLenti-CD74-ROS1 nonmutant | Express CD74-ROS1 fusion (C6;R34) in mammalian cells |
| 183814 | pLenti-CD74-ROS1 G2032R | Express CD74-ROS1 fusion (C6;R34) harboring ROS1 G2032R mutation in mammalian cells |
| 183815 | pLenti-CD74-ROS1 L2000V | Express CD74-ROS1 fusion (C6;R34) harboring ROS1 L2000V mutation in mammalian cells |
| 183816 | pLenti-CD74-ROS1 L2086F | Express CD74-ROS1 fusion (C6;R34) harboring ROS1 L2086F mutation in mammalian cells |
| 183818 | pLenti-CD74-ROS1 S1986F/L2000V | Express CD74-ROS1 fusion (C6;R34) harboring ROS1 S1986F/L2000V mutation in mammalian cells |
| 183819 | pLenti-CD74-ROS1 S1986F/L2086F | Express CD74-ROS1 fusion (C6;R34) harboring ROS1 S1986F/L2086F mutation in mammalian cells |
| 183820 | pLenti-CD74-ROS1 G2032R/L2086F | Express CD74-ROS1 fusion (C6;R34) harboring ROS1 G2032R/L2086F mutation in mammalian cells |
| 183821 | pLenti-CD74-ROS1 S1986F/G2032R | Express CD74-ROS1 fusion (C6;R34) harboring ROS1 S1986F/G2032R mutation in mammalian cells |
| 183822 | pLenti-CD74-ROS1 S1986F/G2032R/L2086F | Express CD74-ROS1 fusion (C6;R34) harboring ROS1 S1986F/G2032R/L2086F mutation in mammalian cells |