A Guillain-Barre syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides.
Alborzian Deh Sheikh A, Gomaa S, Li X, Routledge M, Saigoh K, Numoto N, Angata T, Hitomi Y, Takematsu H, Tsuiji M, Ito N, Kusunoki S, Tsubata T
J Autoimmun. 2021 Jan;116:102571. doi: 10.1016/j.jaut.2020.102571. Epub 2020 Nov 19.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 183722 | pMXs-Sig10-Fc-IG | Expresses the fusion protein containing the extracellular part of human Siglec-10 and the Fc region of human IgG1, and GFP |
| 183723 | pMXs-Sig10(M1)-Fc-IG | Expresses the fusion protein containing the extracellular part of the human Siglec-10 R47Q mutant and the Fc region of human IgG1, and GFP |
| 183724 | pMXs-Sig10(M2)-Fc-IG | Expresses the fusion protein containing the extracellular part of the human Siglec-10 A108V mutant and the Fc region of human IgG1, and GFP |
| 183725 | pMXs-Sig10(DM)-Fc-IG | Expresses the fusion protein containing the extracellular part of the human Siglec-10 R47Q A108V mutant and the Fc region of human IgG1, and GFP |