Addgene: A High-Efficiency AAV for Endothelial Cell Transduction Throughout the Central Nervous System.

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Ben Deverman
Krolak et al

A High-Efficiency AAV for Endothelial Cell Transduction Throughout the Central Nervous System.

Krolak T, Chan KY, Kaplan L, Huang Q, Wu J, Zheng Q, Kozareva V, Beddow T, Tobey IG, Pacouret S, Chen AT, Chan YA, Ryvkin D, Gu C, Deverman BE
Nat Cardiovasc Res. 2022 Apr;1(4):389-400. doi: 10.1038/s44161-022-00046-4. Epub 2022 Apr 13. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

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ID	Plasmid	Purpose
183776	pAAV-CAG-Cre-3xmiR122-WPRE-HGHpA	AAV genome with a CAG driven Cre recombinase with mR122 target sequence repeats to reduce transgene expression in hepatocytes.
183775	pAAV-CAG-SV40NLSf-GFP-3xmiR122-WPRE-HGHpA	AAV genome with a CAG driven eGFP reporter with mR122 target sequence repeats to reduce transgene expression in hepatocytes.
183749	kiCAP-AAV-BI30	AAV-BI30 Rep-Cap plasmid for production of AAV-BI30, a capsid with tropism for CNS endothelial cells.

Antibodies from Article