Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells.
Kath J, Du W, Pruene A, Braun T, Thommandru B, Turk R, Sturgeon ML, Kurgan GL, Amini L, Stein M, Zittel T, Martini S, Ostendorf L, Wilhelm A, Akyuz L, Rehm A, Hopken UE, Pruss A, Kunkele A, Jacobi AM, Volk HD, Schmueck-Henneresse M, Stripecke R, Reinke P, Wagner DL
Mol Ther Methods Clin Dev. 2022 Apr 12;25:311-330. doi: 10.1016/j.omtm.2022.03.018. eCollection 2022 Jun 9.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 183473 | pUC19_HDRT_TRAC_CD19-CAR | Encodes for a homology-directed DNA repair template for the insertion of a second generation CD19-specific CAR into the TRAC gene |