Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells.

Kath J, Du W, Pruene A, Braun T, Thommandru B, Turk R, Sturgeon ML, Kurgan GL, Amini L, Stein M, Zittel T, Martini S, Ostendorf L, Wilhelm A, Akyuz L, Rehm A, Hopken UE, Pruss A, Kunkele A, Jacobi AM, Volk HD, Schmueck-Henneresse M, Stripecke R, Reinke P, Wagner DL
Mol Ther Methods Clin Dev. 2022 Apr 12;25:311-330. doi: 10.1016/j.omtm.2022.03.018. eCollection 2022 Jun 9. PubMed Article

Plasmids from Article

ID	Plasmid	Purpose
183473	pUC19_HDRT_TRAC_CD19-CAR	Encodes for a homology-directed DNA repair template for the insertion of a second generation CD19-specific CAR into the TRAC gene