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Design and Evaluation of Engineered Extracellular Vesicle (EV)-Based Targeting for EGFR-Overexpressing Tumor Cells Using Monobody Display.

Komuro H, Aminova S, Lauro K, Woldring D, Harada M
Bioengineering (Basel). 2022 Jan 29;9(2). pii: bioengineering9020056. doi: 10.3390/bioengineering9020056. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
200162pcS-E626-C1C2This plasmid encodes EGFR targeting monobody (E626) fused to the extracellular vesicle binding domain (C1C2) of lactadherin for surface engineering extracellular vesicles.
200163pcS-RDG-C1C2This plasmid encodes non-binder control monobody (RDG) fused to the extracellular vesicle binding domain (C1C2) of lactadherin for surface engineering extracellular vesicles.

Antibodies from Article