Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins.
Banskota S, Raguram A, Suh S, Du SW, Davis JR, Choi EH, Wang X, Nielsen SC, Newby GA, Randolph PB, Osborn MJ, Musunuru K, Palczewski K, Liu DR
Cell. 2022 Jan 7. pii: S0092-8674(21)01484-7. doi: 10.1016/j.cell.2021.12.021.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 181751 | pCMV-MMLVgag-3xNES-ABE8e | MMLV-Gag fused to 3xNES-ABE8e with TSTLLMENSS cleavage site between Gag-NES and ABE. For production of virus like particles with base-editor RNP cargo. |
| 181752 | pCMV-MMLVgag-3xNES-Cas9 | MMLV-Gag fused to 3x NES-SpyCas9 with the TSTLLMENSS cleavage site in between NES and Cas9. For production of virus like particles with Cas9 nuclease RNP cargo. |
| 181753 | pCMV-MMLVgag-3xNES-ABE7.10-NG | MMLV-Gag fused to 3xNES-ABE7.10-NG with TSTLLMENSS cleavage site between Gag-NES and ABE. For production of virus like particles with base-editor RNP cargo. |
| 181754 | pCMV-MMLVgag-3xNES-ABE8e-NG | MMLV-Gag fused to 3xNES-ABE8e-NG with TSTLLMENSS cleavage site between Gag-NES and ABE. For production of virus like particles with base-editor RNP cargo. |