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The RING domain of Mdm2 can inhibit cell proliferation.

Dang J, Kuo ML, Eischen CM, Stepanova L, Sherr CJ, Roussel MF
Cancer Res. 2002 Feb 15;62(4):1222-30. (Link opens in a new window) PubMed

Plasmids from Article

ID Plasmid Purpose
180487MSCV-mouse Mdm2 wild type-IRES-GFPRole of Mdm2 variants in tumorigenesis
180489MSCV-mouse Mdm2 mutant M2 (299-489)-IRES-GFPRole of Mdm2 variants in tumorigenesis
180490MSCV-mouse Mdm2 mutant M3 (399-489)-IRES-GFPRole of Mdm2 variants in tumorigenesis
180491MSCV-HA tagged-Mouse Mdm2 wt-IRES-GFPRole of Mdm2 splicing variants in tumorigenesis
180493MSCV--Mouse Mdm2 wt-IRES-CFPRole of Mdm2 splicing variants in tumorigenesis

Antibodies from Article