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Broadly neutralizing antibodies target the coronavirus fusion peptide.

Dacon C, Tucker C, Peng L, Lee CD, Lin TH, Yuan M, Cong Y, Wang L, Purser L, Williams JK, Pyo CW, Kosik I, Hu Z, Zhao M, Mohan D, Cooper AJR, Peterson M, Skinner J, Dixit S, Kollins E, Huzella L, Perry D, Byrum R, Lembirik S, Drawbaugh D, Eaton B, Zhang Y, Yang ES, Chen M, Leung K, Weinberg RS, Pegu A, Geraghty DE, Davidson E, Douagi I, Moir S, Yewdell JW, Schmaljohn C, Crompton PD, Holbrook MR, Nemazee D, Mascola JR, Wilson IA, Tan J
Science. 2022 Jul 12:eabq3773. doi: 10.1126/science.abq3773. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
172666pcDNA3.3-NL63-D14encodes NL63 spike protein, for pseudovirus production
180375pcDNA3.3_SARS2_omicron_BA.1Pseudovirus plasmid expressing SARS-CoV-2 omicron BA.1 strain spike protein
183700pcDNA3.3_SARS2_omicron BA.2expressing SARS-CoV-2 BA.2 spike protein for pseudovirus production
186809pcDNA3.3_SARS2_BA.2.12.1pseudovirus plasmid that expresses spike of BA.2.12.1
186810pcDNA3.3_SARS2_BA.4/5pseudovirus plasmid expressing BA.4 and BA.5 spike protein

Antibodies from Article