TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules.
McShan AC, Devlin CA, Papadaki GF, Sun Y, Green AI, Morozov GI, Burslem GM, Procko E, Sgourakis NG
Nat Chem Biol. 2022 Jun 20. pii: 10.1038/s41589-022-01049-9. doi: 10.1038/s41589-022-01049-9.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 178603 | pCEP4-MR1 | Mammalian expression of myc-tagged MR1 |
| 178645 | pCEP4-TAPBPR-TM | Mammalian expression of FLAG-tagged TAPBPR with MHC TM |
| 178650 | pCEP4 TAPBPR-TM-TN6 | Mammalian expression of FLAG-tagged TAPBPR with MHC TM (E205K, R207E, Q209S, Q272S) |
| 178651 | pCEP4-MR1 (M50P) | Mammalian expression of myc-tagged MR1 (M50P) |
| 178652 | pCEP4 MR1 (H83P) | Mammalian expression of myc-tagged MR1 (H83P) |
| 178653 | pCEP4 MR1 (Q153P) | Mammalian expression of myc-tagged MR1 (Q153P) |