Fumarate is a terminal electron acceptor in the mammalian electron transport chain.
Spinelli JB, Rosen PC, Sprenger HG, Puszynska AM, Mann JL, Roessler JM, Cangelosi AL, Henne A, Condon KJ, Zhang T, Kunchok T, Lewis CA, Chandel NS, Sabatini DM
Science. 2021 Dec 3;374(6572):1227-1237. doi: 10.1126/science.abi7495. Epub 2021 Dec 2.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 177976 | pCW57.1 tTA SDHA | All-in-one dox-repressible expression of cDNA |
| 177977 | pCW57.1 tTA SDHB | All-in-one dox-repressible expression of cDNA |
| 177978 | pCW57.1 tTA UQCRC2 | All-in-one dox-repressible expression of cDNA |
| 177979 | pmxs_COX4 | Mammalian expression of COX4 cDNA |
| 177980 | pLentiCRISPRv1_SDHA | lentiviral vector expressing Cas9 and a sgRNA targeting SDHA |
| 177981 | pLentiCRISPRv1_SDHB | lentiviral vector expressing Cas9 and a sgRNA targeting SDHB |
| 177982 | pLentiCRISPRv1_UQCRC2 | lentiviral vector expressing Cas9 and a sgRNA targeting UQCRC2 |
| 177983 | pLentiCRISPRv1_COX4 | lentiviral vector expressing Cas9 and a sgRNA targeting COX4 |
| 177984 | pCW57.1_AOX-FLAG | All-in-one dox-inducible expression of Alternative Oxidase |