Talin variant P229S compromises integrin activation and associates with multifaceted clinical symptoms.
Azizi L, Varela L, Turkki P, Mykuliak VV, Korpela S, Ihalainen TO, Church J, Hytonen VP, Goult BT
Hum Mol Genet. 2022 Jul 21. pii: 6647920. doi: 10.1093/hmg/ddac163.
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Article
Plasmids from this article have been deposited by multiple labs. See below for all materials from each lab:
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 177870 | mTln1-F2-pET151 | Expresses mouse Talin 1 F2 domain in bacterial cells |
| 177871 | mTln1-F2-P229S-pET151 | Expresses mouse Talin 1 F2-P229S domain in bacterial cells |
| 177876 | mTln1-F2-P229L-pET151 | Expresses mouse Talin 1 F2-P229L domain in bacterial cells |
| 177877 | mTln1-F2F3-pET151 | Expresses mouse Talin 1 F2F3 domains in bacterial cells |
| 177878 | mTln1-F2F3-P229S-pET151 | Expresses mouse Talin 1 F2F3-P229S domains in bacterial cells |
| 177879 | mTln1-F2F3-P229L-pET151 | Expresses mouse Talin 1 F2F3-P229L domains in bacterial cells |
| 182992 | Full-length WT talin1 | express FL WT talin1 in mammalian cells |
| 182993 | Full-length P229S talin1 | express FL variant P229S talin1 in mammalian cells |
| 182994 | minitalin (headR13DD) | expression of minitalin wt in mammalian cells |
| 182995 | mini-talin P229S (headR13DD P229S) | expression of minitalin P229S in mammalian cells |
| 182996 | talin1-head | expression of talin1 head wt in mammalian cells |
| 182997 | talin1-head P229S | expression of talin1 head P229S in mammalian cells |