Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.

Holler CJ, Taylor G, Deng Q, Kukar T
eNeuro. 2017 Aug 18;4(4). pii: eN-NWR-0100-17. doi: 10.1523/ENEURO.0100-17.2017. eCollection 2017 Jul-Aug. PubMed Article

Plasmids from Article

ID	Plasmid	Purpose
176915	pcDNA3.1(+)_Paragranulin+linker 1	express Paragranulin with linker 1 in mammalian cells
176917	pcDNA3.1(+)_Paragranulin-no linker	express Paragranulin without linker 1 in mammalian cells
176918	pcDNA3.1(+)_Granulin 1+linker2	express Granulin 1 with linker 2 in mammalian cells
176919	pcDNA3.1(+)_Granulin 1-no linker	express Granulin 1 without linker 2 in mammalian cells
176920	pcDNA3.1(+)_Granulin 2+linker3	express Granulin 2 with linker 3 in mammalian cells
176921	pcDNA3.1(+)_Granulin 2-no linker	express Granulin 2 without linker 3 in mammalian cells
176922	pcDNA3.1(+)_Granulin 3+linker4	express Granulin 3 with linker 4 in mammalian cells
176923	pcDNA3.1(+)_Granulin 3-no linker	express Granulin 3 without linker 4 in mammalian cells
176924	pcDNA3.1(+)_Granulin 4+linker5	express Granulin 4 with linker 5 in mammalian cells
176925	pcDNA3.1(+)_Granulin 4-no linker	express Granulin 4 without linker 5 in mammalian cells
176926	pcDNA3.1(+)_Granulin 5+linker6	express Granulin 5 with linker 6 in mammalian cells
176927	pcDNA3.1(+)_Granulin 5-no linker	express Granulin 5 without linker 6 in mammalian cells
176928	pcDNA3.1(+)_Granulin 6+linker7	express Granulin 6 with linker 7 in mammalian cells
176929	pcDNA3.1(+)_Granulin 6-no linker	express Granulin 6 without linker 7 in mammalian cells
176930	pcDNA3.1(+)_Granulin 7+linker8	express Granulin 7 with linker 8 in mammalian cells
176931	pcDNA3.1(+)_Granulin 7-no linker	express Granulin 7 without linker 8 in mammalian cells