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Tight nanoscale clustering of Fcgamma receptors using DNA origami promotes phagocytosis.

Kern N, Dong R, Douglas SM, Vale RD, Morrissey MA
eLife. 2021 Jun 3;10. pii: 68311. doi: 10.7554/eLife.68311. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
176606NK66To measure Syk intensity in response to ligand clustering using DNA origami
176608NK72To test macrophage engulfment initiation. Lacks the FcyR chain.
176609NK73To test bead engulfment of macrophages.
176610NK83To measure Syk intensity in response to ligand clustering using DNA origami
176611NK85To minimize dimerization between FcRg transmembrane domains, as this cysteine forms a disulfide bridge between y chains. To manipulate ligand spacing.
176612NK88To manipulate ligand spacing.

Antibodies from Article