Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope.
Villiger L, Schmidheini L, Mathis N, Rothgangl T, Marquart K, Schwank G
Mol Ther Nucleic Acids. 2021 Aug 26;26:502-510. doi: 10.1016/j.omtn.2021.08.025. eCollection 2021 Dec 3.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 176477 | p2T-CMV-HNHx-ABEmax7.10HD-BlastR | A-to-G base editor with alternative targeting scope |
| 176478 | p2T-CMV-HNHx-ABE8eHD-BlastR | A-to-G base editor with alternative targeting scope |