SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling.
Salomaa SI, Miihkinen M, Kremneva E, Paatero I, Lilja J, Jacquemet G, Vuorio J, Antenucci L, Kogan K, Hassani Nia F, Hollos P, Isomursu A, Vattulainen I, Coffey ET, Kreienkamp HJ, Lappalainen P, Ivaska J
Curr Biol. 2021 Sep 29. pii: S0960-9822(21)01262-8. doi: 10.1016/j.cub.2021.09.022.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 175254 | EGFP-SPN_ARR wt (Shank3) | SPN-ARR fragment in EGFP backbone for mammalian expression |
| 175255 | EGFP-SPN_ARR N52R (Shank3) | SPN-ARR fragment with structure opening N52R mutation in EGFP backbone for mammalian expression |
| 175256 | EGFP-SPN_ARR Q37A/R38A/N52R (Shank3) | SPN-ARR fragment with structure opening N52R and actin binding site Q37A/R38A mutations in EGFP backbone for mammalian expression |