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Regulated control of gene therapies by drug-induced splicing.

Monteys AM, Hundley AA, Ranum PT, Tecedor L, Muehlmatt A, Lim E, Lukashev D, Sivasankaran R, Davidson BL
Nature. 2021 Jul 28. pii: 10.1038/s41586-021-03770-2. doi: 10.1038/s41586-021-03770-2. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
174659pGL4.10/RSV_SF3B3-Xon_LuciferasePlasmid containing the SF3B3-Xon/Firefly luciferase cassette. Translation of Firefly luciferase is controlled by splicing modulation of the SF3B3-xon by LMI070.
174660pGL4.10/RSV_SF3B3-miniXon_LuciferasePlasmid containing the SF3B3-miniXon/Firefly luciferase cassette. Translation of Firefly luciferase is controlled by splicing modulation of the SF3B3-miniXon by LMI070.

Antibodies from Article