Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis.
Ding Y, Colozza G, Sosa EA, Moriyama Y, Rundle S, Salwinski L, De Robertis EM
Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9135-E9144. doi: 10.1073/pnas.1812117115. Epub 2018 Sep 12.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 172485 | pCS2 Bighead S-HA | for synthesis of mRNA for injection into xenopus laevis embryos |
| 172852 | pCS2-xFAM3b.L-HA | mRNA synthesis for injection into embryos |
| 180147 | pCS2-Bighead S-FC | mRNA synthesis for injection into embryos |