The insertion in the double-stranded RNA binding domain of human Drosha is important for its function.
Zhang X, Li P, Lin J, Huang H, Yin B, Zeng Y
Biochim Biophys Acta Gene Regul Mech. 2017 Dec;1860(12):1179-1188. doi: 10.1016/j.bbagrm.2017.10.004. Epub 2017 Nov 3.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 171532 | pCK-Drosha-FLAG(delta6) | Encodes mutant human Drosha protein |
| 171534 | p3xFLAG-CMV-Drosha (E419) | Encodes mutant human Drosha protein |
| 171535 | p3xFLAG-CMV-Drosha(W1258) | Encodes mutant human Drosha protein |
| 171536 | p3xFLAG-CMV-Drosha(R871) | Encodes mutant human Drosha protein |
| 171537 | p3xFLAG-CMV-Drosha (P426) | Encodes mutant human Drosha protein |
| 171538 | p3xFLAG-CMV-Drosha (NLS-P426) | Encodes mutant human Drosha protein |