Interface-guided phenotyping of coding variants in the transcription factor RUNX1.

Ozturk K, Panwala R, Sheen J, Ford K, Jayne N, Portell A, Zhang DE, Hutter S, Haferlach T, Ideker T, Mali P, Carter H
Cell Rep. 2024 Jul 4;43(7):114436. doi: 10.1016/j.celrep.2024.114436. PubMed Article

Plasmids from Article

ID	Plasmid	Purpose
170924	EF1A_Hygro_P2A_RUNX1_E61V_Barcode	Overexpression of RUNX1 E61V mutant protein.
170925	EF1A_Hygro_P2A_RUNX1_L62P_Barcode	Overexpression of RUNX1 L62P mutant protein.
170926	EF1A_Hygro_P2A_RUNX1_V63E_Barcode	Overexpression of RUNX1 V63E mutant protein.
170927	EF1A_Hygro_P2A_RUNX1_R64P_Barcode	Overexpression of RUNX1 R64P mutant protein.
170928	EF1A_Hygro_P2A_RUNX1_T65I_Barcode	Overexpression of RUNX1 T65I mutant protein.
170929	EF1A_Hygro_P2A_RUNX1_D66V_Barcode	Overexpression of RUNX1 D66V mutant protein.
170930	EF1A_Hygro_P2A_RUNX1_S67R_Barcode	Overexpression of RUNX1 S67R mutant protein.
170931	EF1A_Hygro_P2A_RUNX1_P68R_Barcode	Overexpression of RUNX1 P68R mutant protein.
170932	EF1A_Hygro_P2A_RUNX1_N69Y_Barcode	Overexpression of RUNX1 N69Y mutant protein.
170933	EF1A_Hygro_P2A_RUNX1_L71P_Barcode	Overexpression of RUNX1 L71P mutant protein.
170934	EF1A_Hygro_P2A_RUNX1_V74E_Barcode	Overexpression of RUNX1 V74E mutant protein.
170935	EF1A_Hygro_P2A_RUNX1_P76S_Barcode	Overexpression of RUNX1 P76S mutant protein.
170936	EF1A_Hygro_P2A_RUNX1_T77R_Barcode	Overexpression of RUNX1 T77R mutant protein.
170937	EF1A_Hygro_P2A_RUNX1_H78R_Barcode	Overexpression of RUNX1 H78R mutant protein.
170938	EF1A_Hygro_P2A_RUNX1_W79R_Barcode	Overexpression of RUNX1 W79R mutant protein.
170939	EF1A_Hygro_P2A_RUNX1_R80G_Barcode	Overexpression of RUNX1 R80G mutant protein.
170940	EF1A_Hygro_P2A_RUNX1_C81Y_Barcode	Overexpression of RUNX1 C81Y mutant protein.
170941	EF1A_Hygro_P2A_RUNX1_N82I_Barcode	Overexpression of RUNX1 N82I mutant protein.
170942	EF1A_Hygro_P2A_RUNX1_T84I_Barcode	Overexpression of RUNX1 T84I mutant protein.
170943	EF1A_Hygro_P2A_RUNX1_L85R_Barcode	Overexpression of RUNX1 L85R mutant protein.
170944	EF1A_Hygro_P2A_RUNX1_P86R_Barcode	Overexpression of RUNX1 P86R mutant protein.
170945	EF1A_Hygro_P2A_RUNX1_I87N_Barcode	Overexpression of RUNX1 I87N mutant protein.
170946	EF1A_Hygro_P2A_RUNX1_A88P_Barcode	Overexpression of RUNX1 A88P mutant protein.
170947	EF1A_Hygro_P2A_RUNX1_K90N_Barcode	Overexpression of RUNX1 K90N mutant protein.
170948	EF1A_Hygro_P2A_RUNX1_V92E_Barcode	Overexpression of RUNX1 V92E mutant protein.
170949	EF1A_Hygro_P2A_RUNX1_L94P_Barcode	Overexpression of RUNX1 L94P mutant protein.
170950	EF1A_Hygro_P2A_RUNX1_G95R_Barcode	Overexpression of RUNX1 G95R mutant protein.
170951	EF1A_Hygro_P2A_RUNX1_D96H_Barcode	Overexpression of RUNX1 D96H mutant protein.
170952	EF1A_Hygro_P2A_RUNX1_V97D_Barcode	Overexpression of RUNX1 V97D mutant protein.
170953	EF1A_Hygro_P2A_RUNX1_P98R_Barcode	Overexpression of RUNX1 P98R mutant protein.
170954	EF1A_Hygro_P2A_RUNX1_D99Y_Barcode	Overexpression of RUNX1 D99Y mutant protein.
170955	EF1A_Hygro_P2A_RUNX1_G100V_Barcode	Overexpression of RUNX1 G100V mutant protein.
170956	EF1A_Hygro_P2A_RUNX1_T101I_Barcode	Overexpression of RUNX1 T101I mutant protein.
170957	EF1A_Hygro_P2A_RUNX1_L102P_Barcode	Overexpression of RUNX1 L102P mutant protein.
170958	EF1A_Hygro_P2A_RUNX1_T104I_Barcode	Overexpression of RUNX1 T104I mutant protein.
170959	EF1A_Hygro_P2A_RUNX1_V105E_Barcode	Overexpression of RUNX1 V105E mutant protein.
170960	EF1A_Hygro_P2A_RUNX1_M106R_Barcode	Overexpression of RUNX1 M106R mutant protein.
170961	EF1A_Hygro_P2A_RUNX1_N109Y_Barcode	Overexpression of RUNX1 N109Y mutant protein.
170962	EF1A_Hygro_P2A_RUNX1_D110V_Barcode	Overexpression of RUNX1 D110V mutant protein.
170963	EF1A_Hygro_P2A_RUNX1_E111V_Barcode	Overexpression of RUNX1 E111V mutant protein.
170964	EF1A_Hygro_P2A_RUNX1_N112S_Barcode	Overexpression of RUNX1 N112S mutant protein.
170965	EF1A_Hygro_P2A_RUNX1_Y113N_Barcode	Overexpression of RUNX1 Y113N mutant protein.
170966	EF1A_Hygro_P2A_RUNX1_S114L_Barcode	Overexpression of RUNX1 S114L mutant protein.
170967	EF1A_Hygro_P2A_RUNX1_A115D_Barcode	Overexpression of RUNX1 A115D mutant protein.
170968	EF1A_Hygro_P2A_RUNX1_E116V_Barcode	Overexpression of RUNX1 E116V mutant protein.
170969	EF1A_Hygro_P2A_RUNX1_L117R_Barcode	Overexpression of RUNX1 L117R mutant protein.
170970	EF1A_Hygro_P2A_RUNX1_R118G_Barcode	Overexpression of RUNX1 R118G mutant protein.
170971	EF1A_Hygro_P2A_RUNX1_N119I_Barcode	Overexpression of RUNX1 N119I mutant protein.
170972	EF1A_Hygro_P2A_RUNX1_A120D_Barcode	Overexpression of RUNX1 A120D mutant protein.
170973	EF1A_Hygro_P2A_RUNX1_T121I_Barcode	Overexpression of RUNX1 T121I mutant protein.