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Small-molecule-induced polymerization triggers degradation of BCL6.

Slabicki M, Yoon H, Koeppel J, Nitsch L, Roy Burman SS, Di Genua C, Donovan KA, Sperling AS, Hunkeler M, Tsai JM, Sharma R, Guirguis A, Zou C, Chudasama P, Gasser JA, Miller PG, Scholl C, Frohling S, Nowak RP, Fischer ES, Ebert BL
Nature. 2020 Dec;588(7836):164-168. doi: 10.1038/s41586-020-2925-1. Epub 2020 Nov 18. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
169931BCL6-GFP in ArtichokeOverexpression of Full Length of BCL6-GFP fusion
169932BCL6-GFP (1-275AA) in CilantroOverexpression of 1-275AA BCL6-GFP fusion
169933BCL6-GFP R28A in ArtichokeOverexpression of BCL6-GFP R28A mutant fusion
169935BCL6-GFP G55A in ArtichokeOverexpression of BCL6-GFP G55A mutant fusion
169936BCL6-GFP Y58A in ArtichokeOverexpression of BCL6-GFP Y58A mutant fusion

Antibodies from Article