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EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.
Gautheron J, Morisseau C, Chung WK, Zammouri J, Auclair M, Baujat G, Capel E, Moulin C, Wang Y, Yang J, Hammock BD, Cerame B, Phan F, Feve B, Vigouroux C, Andreelli F, Jeru I
Elife. 2021 Aug 3;10. pii: 68445. doi: 10.7554/eLife.68445. PubMed Article

Plasmids from Article

ID Plasmid Purpose
169169pCMV6-Entry-EPHX1c.337T>C-FlagExpresses EPHX1 c.337T>C in mammalian cells
169170pCMV6-Entry-EPHX1c.416A>G-FlagExpresses EPHX1 c.416A>G in mammalian cells
169171pCMV6-Entry-EPHX1c.997A>C-FlagExpresses EPHX1 c.997A>C in mammalian cells
169172pCMV6-Entry-EPHX1c.1212G>C-FlagExpresses EPHX1 c.1212G>C in mammalian cells
169173pCMV6-Entry-EPHX1c.1288G>C-FlagExpresses EPHX1 c.1288G>C in mammalian cells

Antibodies from Article