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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease.

Canal B, Fujisawa R, McClure AW, Deegan TD, Wu M, Ulferts R, Weissmann F, Drury LS, Bertolin AP, Zeng J, Beale R, Howell M, Labib K, Diffley JFX
Biochem J. 2021 Jul 16;478(13):2465-2479. doi: 10.1042/BCJ20210199. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
169166pBIG1a_3xFlag-6His-nsp15 (SARS-CoV-2)Baculoviral transfer vector for the expression of SARS-CoV-2 nsp15 in insect cells

Antibodies from Article