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Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.

Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Stalls V, Kopp MF, Manne K, Li D, Wiehe K, Saunders KO, Edwards RJ, Korber B, Haynes BF, Henderson R, Acharya P
Science. 2021 Jun 24. pii: science.abi6226. doi: 10.1126/science.abi6226. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
171743pαH-S-GSAS-D614G-deltaFVMammalian expression of SARS-CoV-2 Spike protein mink variant (S-GSAS-D614G-deltaFV variant)
171744pαH-S-GSAS-deltaH69/V70Mammalian expression of SARS-CoV-2 Spike protein S-GSAS-D614G-deltaH69/V70 variant
171745pαH-S-GSAS-D614G-Y453FMammalian expression of SARS-CoV-2 Spike protein S-GSAS-D614G-Y453F variant
171746pαH-S-GSAS-D614G-I692VMammalian expression of SARS-CoV-2 Spike protein S-GSAS-D614G-I692V variant
171747pαH-S-GSAS-B.1.1.7Mammalian expression of SARS-CoV-2 Spike protein S-GSAS-B.1.1.7 variant (UK)
171748pαH-S-GSAS-D614G-N501YMammalian expression of SARS-CoV-2 Spike protein S-GSAS-D614G-N501Y variant
171749pαH-S-GSAS-B.1.351Mammalian expression of SARS-CoV-2 Spike protein S-GSAS-D614G-B.1.351 variant (South African)
171750pαH-S-GSAS-D614G-K417N-E484K-N501YMammalian expression of SARS-CoV-2 Spike protein S-GSAS-D614G-K417N-E484K-N501Y
171751pαH-S-GSAS-D614G-E484KMammalian expression of SARS-CoV-2 Spike protein S-GSAS-D614G-E484K variant
171752pαH-S-GSAS-D614G-K417NMammalian expression of SARS-CoV-2 Spike protein S-GSAS-D614G-K417N variant
173786pαH-S-GSAS-B.1.351.v2Mammalian expression of SARS-CoV-2 Spike protein South African variant version 2
173787pαH-S-GSAS-B.1.351.v3Mammalian expression of SARS-CoV-2 Spike protein South African variant version 3
173788pαH-S-GSAS-B.1.351.v4Mammalian expression of SARS-CoV-2 Spike protein South African variant version 4
173789pαH-S-GSAS-P1-likeMammalian expression of SARS-CoV-2 Spike protein P-1-like variant (K417N)
173790pαH-S-GSAS-B.1.351.v5Mammalian expression of SARS-CoV-2 Spike protein South African variant version 5
173791pαH-S-GSAS-B.1.351.v6Mammalian expression of SARS-CoV-2 Spike protein South African variant version 6

Antibodies from Article