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PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling.

Addis Jones O, Tiwari A, Olukoga T, Herbert A, Chan KL
Nat Commun. 2019 Jun 28;10(1):2861. doi: 10.1038/s41467-019-10938-y. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
110300pSpCas9(BB)-2A-Neo_h53BP1_gRNA_DExpresssion of Cas9-T2A-neomycin resistant gene and a gRNA targeting exon 10 of human 53BP1

Antibodies from Article