Concerted evolution reveals co-adapted amino acid substitutions in Na(+)K(+)-ATPase of frogs that prey on toxic toads.
Mohammadi S, Yang L, Harpak A, Herrera-Alvarez S, Del Pilar Rodriguez-Ordonez M, Peng J, Zhang K, Storz JF, Dobler S, Crawford AJ, Andolfatto P
Curr Biol. 2021 Jun 21;31(12):2530-2538.e10. doi: 10.1016/j.cub.2021.03.089. Epub 2021 Apr 21.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 167170 | R | Expresses the full Leptodactylus latrans Na+K+ATPase with ATP1A1-R variant in Sf9 cells |
| 167172 | S | Expresses the full Leptodactylus latrans Na+K+ATPase with ATP1A1-S variant in Sf9 cells |
| 167173 | S+Q111R | Expresses the full Leptodactylus latrans Na+K+ATPase with ATP1A1-S variant with Q111R mutation in Sf9 cells |
| 167174 | S+N122D | Expresses the full Leptodactylus latrans Na+K+ATPase with ATP1A1-S variant with N122D mutation in Sf9 cells |
| 167175 | S+Q111R+N122D | Expresses the full Leptodactylus latrans Na+K+ATPase with ATP1A1-S variant with Q111R and N122D mutations in Sf9 cells |
| 167176 | S+10subs | Expresses the full Leptodactylus latrans Na+K+ATPase with ATP1A1-S variant with 10 R mutations in Sf9 cells |
| 167177 | S+12subs | Expresses the full Leptodactylus latrans Na+K+ATPase with ATP1A1-S variant with 12 R mutations in Sf9 cells |
| 167178 | R-Q111R-N122D | Expresses the full Leptodactylus latrans Na+K+ATPase with ATP1A1-R variant with reverted Q111R and N122D mutations in Sf9 cells |